845 HDL composition, particle number and size is associated with non-calcified coronary plaque in psoriasis

There is an evolving appreciation that high-density lipoproteins (HDL) highly heterogeneous in both composition and function. With the advent of advanced lipid-testing techniques allow for quantitation recovery individual particle populations, we are beginning to connect functionality HDL subspecies with chronic inflammatory diseases. Psoriasis (PSO), provides a reliable human model study how may relate non-calcified coronary plaque burden (NCB). We hypothesized would directly associate NCB beyond traditional cardiovascular risk factors. Methods: Patients severe PSO (45) without known disease who were candidates biologic therapy underwent CCTA (320 detector, Toshiba) quantification using QAngio (Medis). All patients had fasting blood draws measurement composition. Results: subjects middle aged 46.8 (±SD 11.2) predominantly men(80%). was negatively associated multiple parameters including HDL-concentration (β=-.55; p=.001), number (β=-.41;p=.007), size (β=-.44; p=.009) large (β=-.54;p=.001) after adjusting age, sex, hypertension, hyperlipidemia, diabetes mellitus statin use. Furthermore, higher than median worse cardiometabolic profile lower concentration, size. Conclusions: psoriasis serve as biomarker subclinical atherosclerosis.